Diketone Based Cu(II), Ni(II) and Zn(II) Complexes Containing N2O2 Donor Ligand: Synthesis, Characterization, DNA Binding and Cleavage Studies
نویسندگان
چکیده
A new series of Schiff base Cu(II), Ni(II) and Zn(II) complexes have been designed and synthesized using the ligand(1,2,8,9-Tetraphenyl-3,7-diazaduohepta-2,7-diene-1,9-dione) which is obtained from the condensation of benzil and 1,3-diaminopropane. The ligand and their complexes have been characterized with the aid of FT-IR, NMR, Mass, elemental analysis, EPR and absorption studies. The interactions of the synthesized complexes with calf thymus (CT) DNA have been investigated by absorption, emission, viscosity and circular dichoric techniques. It was found that all the complexes binds with CT-DNA presumably via an intercalation mechanism with an intrinsic binding constant (Kb) values of 8.6 x 10 M, 8.3 x 10 M and 7.8 x 10 M respectively which are generated from absorption experiment. All the complexes shows efficient oxidative cleavage of SC-DNA involving singlet oxygen species as evidenced from the control data showing inhibition of DNA cleavage in the presence of sodium azide and L-histidine.
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